Creating trust in wireless solutions and increasing their social acceptance are major challenges in achieving the full potential of the Internet of Things (IoT). SCOTT will provide comprehensive cost-efficient solutions for end-to-end secure, trustworthy wireless connectivity and interoperability, to bridge the last mile to market implementation. SCOTT will not just deal with 'things that are connected', but with 'trustable things that securely communicate', i.e. things interconnected by dependable wireless technology and valuing the end-users' privacy rules. SCOTT uses a standardised multi-domain reference architecture, created in a predecessor project, DEWI and its “Bubble concept”. SCOTT has a clearly use-case driven approach, with 15 use cases from different areas of high relevance to European society and industry, with a specific focus on cross-domain use cases and heterogeneous environments, emphasizing 5G and cloud computing aspects to build up digital ecosystems and achieve a broader market penetration. More than 20 demonstrators all over Europe will show tangible results from all use cases to a broader public. distributed cloud integration, energy efficiency/autonomy of devices and reference architecture/implementations, which are all necessary to realize the SCOTT use cases will facilitate composability of systems as well as cross-domain sharing of trustable wireless technologies and services. SCOTT project consortium covers the full value chain from silicon to end-users and operators. By providing reference implementations, SCOTT will establish an eco-system for trustable wireless solutions and services for both professional and private users by attracting 3rd parties and particularly SMEs. The involvement of open innovation approaches and stakeholder engagement as well as close cooperation with AIOTI (Alliance for Internet of Things Innovation), and other cluster organizations all over Europe will further boost and exploit the growing “Internet economy”. SCOTT will open up new market opportunities for European industry will significantly reduce time to market and decrease costs for trustable wireless solutions on the market, in particular by using new designs and technical building blocks. SCOTT will develop methods and tools capable of meeting prospect use-case requirements on reliability, robustness, security and functional safety even in harsh and/or not trusted environments. Ultimately, SCOTT will foster the European leadership for Smart and Connected Things (including Internet of Things) and will strengthen Europe’s independence for security enabling components and systems.